Characterization and antivirus activities of a novel bovine IFN-omega24
X Luo, Y Guo, J Bao, Y Liu, D An, B Ma, M Gao… - Molecular …, 2015 - Elsevier
A novel bovine interferon-ω (BoIFN-ω) gene, which encodes a protein of 195 amino acids
with a 23-amino acid signal peptide, was amplified from bovine liver genomic DNA through
PCR and named BoIFN-ω24 according to its position in the bovine genome. In this study, the
recombinant protein was expressed in Escherichia coli and antiviral or antiproliferation
activity was determined in vitro. Results showed that BoIFN-ω24 exhibits high antiviral
activity, which can be abrogated using PAb against BoIFN-ω24, and inhibits cell …
with a 23-amino acid signal peptide, was amplified from bovine liver genomic DNA through
PCR and named BoIFN-ω24 according to its position in the bovine genome. In this study, the
recombinant protein was expressed in Escherichia coli and antiviral or antiproliferation
activity was determined in vitro. Results showed that BoIFN-ω24 exhibits high antiviral
activity, which can be abrogated using PAb against BoIFN-ω24, and inhibits cell …
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